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KMID : 0043319990220060585
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Archives of Pharmacal Research
1999 Volume.22 No. 6 p.585 ~ p.591
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Development of New Dihydropyran Linker for Solid-Phase Reaction
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Ryu Joon-Hyung
Jeong Jin-Hyun
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Abstract
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The linker which plays a role in connecting a polymer with a scaffold has become an important part n solid-phase reaction. To develop a new linker for alcohols and carbohydrates, dihydropyran moiety was selected in this study. New linker, 1-(-dihydro-5H-pyranyl)-7-hydroxyheptan-3-one (5) was synthesized via four steps from -valerolactone. This can be called as DDHP-linked Wang resin due to double dihy-dropyran rings. To the one pyran ring of new linker 5 was added Wang resin and other alcohols and carbohydrates as scaffolds were then added successfully to the another pyran ring. Carbohydrate and hydroxyl resins were connected via new linker in a 70% loading yield. The detachment of glucose moiety in the presence of PPTS (2 equiv.) in 1:1 n-buteanol/1,2-dichloroethane at for 12 h was carried out quantitatively. When certain combinatorial chemical works are carried out using this dihydropyran linker, Wang resin itself can be recovered. Its fact is particularly very important in industry, because recovered resins can be recycled.
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KEYWORD
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Dihydropyran linker, Carbohydrate library, Combinatorial chemistry, Solid-phase reaction Wang resin, DDHP resin
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